Differential uptake, kinetics and mechanisms of intracellular trafficking of next-generation antisense oligonucleotides across human cancer cell lines-Reference-Cited by-同舟云学术

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Differential uptake, kinetics and mechanisms of intracellular trafficking of next-generation antisense oligonucleotides across human cancer cell lines

Published:2019-03-30 Issue:9 Volume:47 Page:4375-4392
ISSN:0305-1048
Container-title:Nucleic Acids Research
language:en
Short-container-title:

Author:

Linnane Emily¹^ORCID,Davey Paul²,Zhang Pei¹,Puri Sanyogitta³,Edbrooke Mark¹,Chiarparin Elisabetta²,Revenko Alexey S⁴,Macleod A Robert⁴,Norman Jim C⁵⁶,Ross Sarah J¹

Affiliation:

1. Bioscience, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, CB10 1XL, UK

2. Chemistry, Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, CB4 0WG, UK

3. Advanced Drug Delivery, Pharmaceutical Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, CB21 6GH, UK

4. Ionis Pharmaceuticals, Carlsbad, CA 92010, USA

5. Cancer Research UK Beatson Institute, Glasgow, G61 1BD, UK

6. Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK

Funder

AstraZeneca

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

http://academic.oup.com/nar/article-pdf/47/9/4375/28603141/gkz214.pdf

Reference46 articles.

1. RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform;Bennett;Annu. Rev. Pharmacol. Toxicol.,2010

2. The rates of the major steps in the molecular mechanism of RNase H1-dependent antisense oligonucleotide induced degradation of RNA;Vickers;Nucleic Acids Res.,2015

3. TricycloDNA-modified oligo-2′-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues–a comparative study of oligonucleotide length, design and chemistry;Murray;Nucleic Acids Res.,2012

4. Short antisense oligonucleotides with novel 2′-4′ conformationaly restricted nucleoside analogues show improved potency without increased toxicity in animals;Seth;J. Med. Chem.,2009

5. AZD9150, a next-generation antisense oligonucleotide inhibitor of STAT3 with early evidence of clinical activity in lymphoma and lung cancer;Hong;Sci. Transl. Med.,2015

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