Short Antisense Oligonucleotides with Novel 2′−4′ Conformationaly Restricted Nucleoside Analogues Show Improved Potency without Increased Toxicity in Animals-Reference-Cited by-同舟云学术

Short Antisense Oligonucleotides with Novel 2′−4′ Conformationaly Restricted Nucleoside Analogues Show Improved Potency without Increased Toxicity in Animals

Published:2008-12-16 Issue:1 Volume:52 Page:10-13
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Seth Punit P.¹,Siwkowski Andrew¹,Allerson Charles R.¹,Vasquez Guillermo¹,Lee Sam¹,Prakash Thazha P.¹,Wancewicz Edward V.¹,Witchell Donna¹,Swayze Eric E.¹

Affiliation:

1. Isis Pharmaceuticals, 1891 Rutherford Road, Carlsbad, California 92008

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm801294h

Reference19 articles.

1. Crooke, S. T.Antisense Drug Technology: Principles, Strategies, and Applications,2nd ed.CRC Press:Boca Raton, FL,2007; p799.

2. Physicochemical properties of phospborothioate oligodeoxynucleotides

3. Phosphorothioate Oligodeoxynucleotides: What Is Their Origin and What Is Unique About Them?

4. Evaluation of 2‘-modified oligonucleotides containing 2‘-deoxy gaps as antisense inhibitors of gene expression

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