Acute Promyelocytic Leukemia with a BCR-ABL1 Rearrangement in a Minor Clone-Reference-Cited by-同舟云学术

Acute Promyelocytic Leukemia with a BCR-ABL1 Rearrangement in a Minor Clone

Published:2021-11-02 Issue: Volume: Page:
ISSN:0007-5027
Container-title:Laboratory Medicine
language:en
Short-container-title:

Author:

Cho Yonggeun¹^ORCID,Hyun Jungwon²,Kim Miyoung³^ORCID,Han Boram⁴,Lee Young Kyung¹

Affiliation:

1. Department of Laboratory Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of Korea

2. Department of Laboratory Medicine, Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong, Republic of Korea

3. Department of Laboratory Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

4. Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, Republic of Korea

Abstract

Abstract Acute promyelocytic leukemia (APL) is a type of acute myeloid leukemia characterized by predominating abnormal promyelocytes with a PML-RARA rearrangement or a variant thereof. BCR-ABL1 rearrangement is an oncogenic event that is usually associated with chronic myeloid leukemia but also occurs in both acute lymphoblastic and acute myeloid leukemias and in healthy individuals. However, APL with concurrent PML-RARA and BCR-ABL1 rearrangements has rarely been reported. Herein, we describe a patient with APL exhibiting a BCR-ABL1 rearrangement in a minor clone and discuss the importance of evaluating this genetic alteration in terms of pathogenesis and treatment.

Publisher

Oxford University Press (OUP)

Subject

Biochemistry, medical,Clinical Biochemistry

Link

http://academic.oup.com/labmed/advance-article-pdf/doi/10.1093/labmed/lmab097/41042709/lmab097.pdf

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