BCR-ABL1 gene rearrangement as a subclonal change in ETV6-RUNX1–positive B-cell acute lymphoblastic leukemia

Author:

Dun Karen A.1,Vanhaeften Rob2,Batt Tracey J.3,Riley Louise A.1,Diano Giuseppe1,Williamson Jan2

Affiliation:

1. Cytogenetics Laboratory,

2. Molecular Medicine Laboratory, and

3. Department of Haematology, Royal Hobart Hospital, Hobart, TAS, Australia

Abstract

Key Points BCR-ABL1 rearrangement as a subclonal change in ETV6-RUNX1–positive B-ALL is a rare occurrence not previously reported. The prognosis of this rare subclonal change has not been determined, yet inclusion of tyrosine kinase inhibitors in treatment is ubiquitous.

Publisher

American Society of Hematology

Subject

Hematology

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