Theoretical study of enzymatic catalysis explains why the trapped covalent intermediate in the E303C mutant of glycosyltransferase GTB was not detected in the wild-type enzyme

Author:

Bobovská Adela,Tvaroška Igor,Kóňa Juraj

Publisher

Oxford University Press (OUP)

Subject

Biochemistry

Reference37 articles.

1. ABO(H) blood group A and B glycosyltransferases recognize substrate via specific conformational changes;J Biol Chem,2008

2. The molecular mechanism of enzymatic glycosyl transfer with retention of configuration: Evidence for a short-lived oxocarbenium-like species;Angew Chem Int Ed,2011

3. Very fast prediction and rationalization of pK(a) values for protein-ligand complexes;Proteins Struct Funct Bioinf,2008

4. Biosynthesis of terminal “Gal-Alpha-1-]3gal-beta-1-]4glcnac-R oligosaccharide sequences on glycoconjugates – Purification and acceptor specificity of a UDP-Gal-N-acetyllactosaminide alpha-]3-galactosyltransferase from calf thymus;J Biol Chem,1985

5. A theoretical study on the catalytic mechanism of the retaining alpha-1,2-mannosyltransferase Kre2p/Mnt1p: The impact of different metal ions on catalysis;Org Biomol Chem,2014

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