How inverting β-1,4-galactosyltransferase-1 can quench a high charge of the by-product UDP3−in catalysis: a QM/MM study of enzymatic reaction with native and UDP-5′ thio galactose substrates

Author:

Kóňa J.12345ORCID

Affiliation:

1. Institute of Chemistry

2. Center for Glycomics

3. Slovak Academy of Sciences

4. 84538 Bratislava

5. Slovak Republic

Abstract

The function of Asp252 in the catalysis of β-1,4-galactosyltransferase-1 may be the stabilization of a high charge of the by-product UDP3−by a substrate-assisted proton transfer reaction.

Funder

Agentúra na Podporu Výskumu a Vývoja

Vedecká Grantová Agentúra MŠVVaŠ SR a SAV

Slovenská Akadémia Vied

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Reference95 articles.

1. Structure and catalytic cycle of β-1,4-galactosyltransferase

2. P. K. Qasba and B.Ramakrishnan , in Comprehensive Glycoscience. From Chemistry to Systems Biology , ed. J. P. Kamerling , G. J. Boons , Y. C. Lee , A. Suzuki , N. Taniguchi and A. G. J. Voragen , Elsevier Ltd. , Oxford , 2007 , vol. 2 , pp. 251–281

3. Structural Snapshots of β-1,4-Galactosyltransferase-I Along the Kinetic Pathway

4. The role of alpha-lactalbumin and the A protein in lactose synthetase: a unique mechanism for the control of a biological reaction.

5. Some Kinetic Properties of Human-Milk Galactosyl Transferase

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