Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs-Reference-Cited by-同舟云学术

Improved specificity of gene silencing by siRNAs containing unlocked nucleobase analogs

Published:2010-11-02 Issue:5 Volume:39 Page:1823-1832
ISSN:1362-4962
Container-title:Nucleic Acids Research
language:en
Short-container-title:

Author:

Vaish Narendra,Chen Feng,Seth Shaguna,Fosnaugh Kathy,Liu Yan,Adami Roger,Brown Tod,Chen Yan,Harvie Pierrot,Johns Rachel,Severson Gregory,Granger Brian,Charmley Patrick,Houston Michael,Templin Michael V.,Polisky Barry

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

http://academic.oup.com/nar/article-pdf/39/5/1823/16781768/gkq961.pdf

Reference25 articles.

1. Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application;Jackson;Nat. Rev. Drug Discov.,2010

2. UNA (unlocked nucleic acid): A flexible RNA mimic that allows engineering of nucleic acid duplex stability;Langkjær;Bioorg. Med. Chem.,2009

3. A large-scale chemical modification screen identifies design rules to generate siRNAs with high activity, high stability and low toxicity;Bramsen;Nucleic Acids Res.,2009

4. Analysis of acyclic nucleoside modifications in siRNAs finds sensitivity at position 1 that is restored by 5′-terminal phosphorylation both in vitro and in vivo;Kenski;Nucleic Acids Res.,2010

5. Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo;Laursen;Molecular BioSystems,2010

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