Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo-Reference-Cited by-同舟云学术

Utilization of unlocked nucleic acid (UNA) to enhance siRNA performance in vitro and in vivo

Published:2010 Issue:5 Volume:6 Page:862
ISSN:1742-206X
Container-title:Molecular BioSystems
language:en
Short-container-title:Mol. BioSyst.

Author:

Laursen Maria B.,Pakula Malgorzata M.,Gao Shan,Fluiter Kees,Mook Olaf R.,Baas Frank,Langklær Niels,Wengel Suzy L.,Wengel Jesper,Kjems Jørgen,Bramsen Jesper B.

Publisher

Royal Society of Chemistry (RSC)

Subject

Molecular Biology,Biotechnology

Link

http://pubs.rsc.org/en/content/articlepdf/2010/MB/B918869J

Reference30 articles.

1. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs

2. Activity of stabilized short interfering RNA in a mouse model of hepatitis B virus replication

3. Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs

4. Functional polarity is introduced by Dicer processing of short substrate RNAs

5. Improved silencing properties using small internally segmented interfering RNAs

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