2′-O-Alkyl-N3-Methyluridine Functionalized Passenger Strand Improves RNAi Activity by Modulating the Thermal Stability-Reference-Cited by-同舟云学术

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2′-O-Alkyl-N³-Methyluridine Functionalized Passenger Strand Improves RNAi Activity by Modulating the Thermal Stability

Published:2024-07-16 Issue:8 Volume:15 Page:1250-1259
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Sahoo Avijit¹,Gupta Shalini²,Das Gourav¹,Ghosh Atanu²,Bagale Siddharam Shivappa³,Sinha Surajit²^ORCID,Gore Kiran R.¹^ORCID

Affiliation:

1. Department of Chemistry, Indian Institute of Technology Kharagpur, West Bengal 721302, India

2. School of Applied and Interdisciplinary Sciences, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700032, India

3. Department of Chemistry, Indian Institute of Technology Bombay, Mumbai 400076, India

Funder

Council of Scientific and Industrial Research, India

Science and Engineering Research Board

Indian Institute of Technology Kharagpur

Indian Institute of Technology Bombay

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.4c00140

Reference36 articles.

1. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

2. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

3. Therapeutic siRNA: State-of-the-Art and Future Perspectives

4. Chemically modified siRNA: tools and applications

5. Chemistry, structure and function of approved oligonucleotide therapeutics

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