Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66Shc transcription and vascular oxidative stress in obesity

Author:

Costantino Sarah12,Paneni Francesco12,Virdis Agostino3,Hussain Shafaat1,Mohammed Shafeeq Ahmed12,Capretti Giuliana4,Akhmedov Alexander2,Dalgaard Kevin5,Chiandotto Sergio4,Pospisilik J Andrew5,Jenuwein Thomas5,Giorgio Marco6,Volpe Massimo47,Taddei Stefano3,Lüscher Thomas F2,Cosentino Francesco1

Affiliation:

1. Cardiology Unit, Department of Medicine Solna, Karolinska Institute and Karolinska University Hospital, Solnavägen, 171 76 Stockholm, Sweden

2. Center for Molecular Cardiology, University of Zürich, Wagistrasse 12, Schlieren, Switzerland

3. Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

4. Cardiology, Department of Clinical and Molecular Medicine, University of Rome Sapienza, Via di Grottarossa, 1035, Rome, Italy

5. Department of Epigenetics, Max Planck Institute of Immunology, Stuebeweg 51, Freiburg, Germany

6. Department of Experimental Oncology, Institute of Oncology, Via Adamello 16, Milano, Italy

7. Department of Angio–Cardio–Neurology, IRCCS Neuromed, Pozzilli, Italy

Funder

Vetenskaprådet

Drottning Victorias Frimurarestiftelse

Swedish Heart-Lung Foundation

EFSD

Novo Nordisk Award, and Italian Ministry of Education, University and Research

Center for Gender Medicine and the Holcim Stiftung

Jubiläumsstiftung

Foundation for Cardiovascular Research

Zürich Heart House, Zürich Switzerland

Swiss National Research Foundation

Sheikh Khalifa’s Foundation Assistant Professorship

Faculty of Medicine, University of Zurich

Publisher

Oxford University Press (OUP)

Subject

Cardiology and Cardiovascular Medicine

Reference37 articles.

1. Surgical management of obesity and the relationship to cardiovascular disease;Vest;Circulation,2013

2. Obesity and severe obesity forecasts through 2030;Finkelstein;Am J Prev Med,2012

3. Body fat distribution and risk of cardiovascular disease: an update;Despres;Circulation,2012

4. ESC guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD: the task force on diabetes, pre-diabetes, and cardiovascular diseases of the European Society of Cardiology (ESC) and developed in collaboration with the European Association for the Study of Diabetes (EASD);Authors/Task Force M;Eur Heart J,2013

5. Prognostic impact of body weight and abdominal obesity in women and men with cardiovascular disease;Dagenais;Am Heart J,2005

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