1. Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A. Gemelli—IRCCS , Largo A. Gemelli 8, Rome 00168 , Italy
2. Department of Cardiovascular and Pulmonary Sciences, Catholic University, School of Medicine , Largo F. Vito 1, 00168 Rome , Italy
3. Department of Pharmacology, Catholic University School of Medicine , Largo F. Vito 1, 00168 Rome , Italy