ncdDetect2: improved models of the site-specific mutation rate in cancer and driver detection with robust significance evaluation

Author:

Juul Malene12ORCID,Madsen Tobias12,Guo Qianyun2,Bertl Johanna1,Hobolth Asger2,Kellis Manolis3,Pedersen Jakob Skou12

Affiliation:

1. Department of Molecular Medicine, Aarhus University, Palle Juul-Jensens Boulevard 99, DK-8200 Aarhus N, Denmark

2. Bioinformatics Research Centre, Aarhus University, C.F. Mollers Alle 8, DK-8000 Aarhus C, Denmark

3. Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA

Funder

Sapere Aude

JSP

Innovation Fund Denmark

Independent Research Fund Denmark

Publisher

Oxford University Press (OUP)

Subject

Computational Mathematics,Computational Theory and Mathematics,Computer Science Applications,Molecular Biology,Biochemistry,Statistics and Probability

Reference31 articles.

1. Controlling the false discovery rate: a practical and powerful approach to multiple testing;Benjamini;J. R. Stat. Soc. Ser. B (Methodological),1995

2. A site specific model and analysis of the neutral somatic mutation rate in whole-genome cancer data;Bertl;BMC Bioinformatics,2018

3. Impact of replication timing on non-CpG and CpG substitution rates in mammalian genomes;Chen;Genome Res,2010

4. An integrated encyclopedia of DNA elements in the human genome;ENCODE Project Consortium and others;Nature,2012

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