Non-coding driver mutations in human cancer
Author:
Publisher
Springer Science and Business Media LLC
Subject
General Earth and Planetary Sciences,General Environmental Science
Link
http://www.nature.com/articles/s41568-021-00371-z.pdf
Reference109 articles.
1. Huang, F. W. et al. Highly recurrent TERT promoter mutations in human melanoma. Science 339, 957–959 (2013).
2. Horn, S. et al. TERT promoter mutations in familial and sporadic melanoma. Science 339, 959–961 (2013). Together with Huang et al. (2013), this paper establishes non-coding somatic promoter mutations as a mechanism for oncogene activation.
3. Garraway, L. A. & Lander, E. S. Lessons from the cancer genome. Cell 153, 17–37 (2013).
4. The ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium. Pan-cancer analysis of whole genomes. Nature 578, 82–93 (2020).
5. Rheinbay, E. et al. Analyses of non-coding somatic drivers in 2,658 cancer whole genomes. Nature 578, 102–111 (2020). As the largest and most ambitious pan-cancer study of non-coding somatic mutations to date, this large consortium effort confirmed high prevalence of TERT promoter mutations in human cancer and also suggested additional lower-frequency candidates.
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