Thermometer: a webserver to predict protein thermal stability

Author:

Miotto Mattia12,Armaos Alexandros3,Di Rienzo Lorenzo2,Ruocco Giancarlo12,Milanetti Edoardo12,Tartaglia Gian Gaetano23ORCID

Affiliation:

1. Department of Physics, Sapienza University of Rome , 00185 Rome, Italy

2. Center for Life Nano & Neuroscience, Italian Institute of Technology , 00161 Rome, Italy

3. Department of Biology, Sapienza University of Rome , 00185 Rome, Italy

Abstract

Abstract Motivation Thermal properties of proteins are of great importance for a number of theoretical and practical implications. Predicting the thermal stability of a protein is a difficult and still scarcely addressed task. Results Here, we introduce Thermometer, a webserver to assess the thermal stability of a protein using structural information. Thermometer is implemented as a publicly available, user-friendly interface. Availability and implementation Our server can be found at the following link (all major browser supported): http://service.tartaglialab.com/new_submission/thermometer_file. Supplementary information Supplementary data are available at Bioinformatics online.

Funder

European Research Council

Publisher

Oxford University Press (OUP)

Subject

Computational Mathematics,Computational Theory and Mathematics,Computer Science Applications,Molecular Biology,Biochemistry,Statistics and Probability

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