Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs
Author:
Affiliation:
1. Alnylam Pharmaceuticals, Inc., Cambridge, MA 02142, USA
2. Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA
Abstract
Funder
Argonne National Laboratory
Michigan Economic Development Corporation
Alnylam Pharmaceuticals
Publisher
Oxford University Press (OUP)
Subject
Genetics
Link
http://academic.oup.com/nar/article-pdf/49/19/10851/41071028/gkab916.pdf
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5. Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect;Ui-Tei;Nucleic Acids Res.,2008
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