Voriconazole-Resistant Penicillium oxalicum: An Emerging Pathogen in Immunocompromised Hosts

Author:

Chowdhary Anuradha1,Kathuria Shallu1,Agarwal Kshitij2,Sachdeva Neelam3,Singh Pradeep K.1,Jain Sandeep3,Meis Jacques F.45

Affiliation:

1. Vallabhbhai Patel Chest Institute, University of Delhi, Delhi, India

2. Rajan Babu Institute of Pulmonary Medicine and Tuberculosis, Delhi, India

3. Rajiv Gandhi Cancer Institute & Research Centre, Delhi, India

4. Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands

5. Radboud University Medical Centre, Nijmegen, The Netherlands

Abstract

Abstract Penicillium species are rarely reported agents of infections in immunocompromised patients. We report 3 cases of invasive mycosis caused by voriconazole-resistant Penicillium oxalicum in patients with acute myeloid leukemia, diabetes mellitus, and chronic obstructive pulmonary disease, while on voriconazole therapy. Penicillium oxalicum has not been previously recognized as a cause of invasive mycoses.

Publisher

Oxford University Press (OUP)

Subject

Infectious Diseases,Oncology

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