1. Department of Biochemistry and Biotechnology, State University of Londrina , P.O. box 10.011, Londrina, PR, 86057-970 , Brazil
2. Department of Pathological Sciences, State University of Londrina , P.O. box 10.011, Londrina, PR, 86057-970 , Brazil
3. Department of Chemistry, State University of Londrina , P.O. box 10.011, Londrina, PR, 86057-970 , Brazil
4. Department of General Biology, State University of Londrina , P.O. box 10.011, Londrina, PR, 86057-970 , Brazil