The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver-Reference-Cited by-同舟云学术

The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver

Published:2009-07-30 Issue:21 Volume:18 Page:4081-4088
ISSN:1460-2083
Container-title:Human Molecular Genetics
language:en
Short-container-title:

Author:

Beer Nicola L.,Tribble Nicholas D.,McCulloch Laura J.,Roos Charlotta,Johnson Paul R.V.,Orho-Melander Marju,Gloyn Anna L.

Publisher

Oxford University Press (OUP)

Subject

Genetics (clinical),Genetics,Molecular Biology,General Medicine

Reference30 articles.

1. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels;Saxena;Science,2007

2. A common missense variant in the glucokinase regulatory protein gene (GCKR) is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations;Orho-Melander;Diabetes,2008

3. The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes;Sparso;Diabetologia,2008

4. The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population;Vaxillaire;Diabetes,2008

5. Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes;Matschinsky;Diabetes,1990

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