Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels
Author:
Saxena Richa12345, Voight Benjamin F.12345, Lyssenko Valeriya12345, Burtt Noël P.12345, de Bakker Paul I. W.12345, Chen Hong12345, Roix Jeffrey J.12345, Kathiresan Sekar12345, Hirschhorn Joel N.12345, Daly Mark J.12345, Hughes Thomas E.12345, Groop Leif12345, Altshuler David12345, Almgren Peter12345, Florez Jose C.12345, Meyer Joanne12345, Ardlie Kristin12345, Bengtsson Boström Kristina12345, Isomaa Bo12345, Lettre Guillaume12345, Lindblad Ulf12345, Lyon Helen N.12345, Melander Olle12345, Newton-Cheh Christopher12345, Nilsson Peter12345, Orho-Melander Marju12345, Råstam Lennart12345, Speliotes Elizabeth K.12345, Taskinen Marja-Riitta12345, Tuomi Tiinamaija12345, Guiducci Candace12345, Berglund Anna12345, Carlson Joyce12345, Gianniny Lauren12345, Hackett Rachel12345, Hall Liselotte12345, Holmkvist Johan12345, Laurila Esa12345, Sjögren Marketa12345, Sterner Maria12345, Surti Aarti12345, Svensson Margareta12345, Svensson Malin12345, Tewhey Ryan12345, Blumenstiel Brendan12345, Parkin Melissa12345, DeFelice Matthew12345, Barry Rachel12345, Brodeur Wendy12345, Camarata Jody12345, Chia Nancy12345, Fava Mary12345, Gibbons John12345, Handsaker Bob12345, Healy Claire12345, Nguyen Kieu12345, Gates Casey12345, Sougnez Carrie12345, Gage Diane12345, Nizzari Marcia12345, Gabriel Stacey B.12345, Chirn Gung-Wei12345, Ma Qicheng12345, Parikh Hemang12345, Richardson Delwood12345, Ricke Darrell12345, Purcell Shaun12345
Affiliation:
1. Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA 02142, USA. 2. Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA. 3. Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. 4. Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA. 5. Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Abstract
New strategies for prevention and treatment of type 2 diabetes (T2D) require improved insight into disease etiology. We analyzed 386,731 common single-nucleotide polymorphisms (SNPs) in 1464 patients with T2D and 1467 matched controls, each characterized for measures of glucose metabolism, lipids, obesity, and blood pressure. With collaborators (FUSION and WTCCC/UKT2D), we identified and confirmed three loci associated with T2D—in a noncoding region near
CDKN2A
and
CDKN2B
, in an intron of
IGF2BP2
, and an intron of
CDKAL1
—and replicated associations near
HHEX
and in
SLC30A8
found by a recent whole-genome association study. We identified and confirmed association of a SNP in an intron of glucokinase regulatory protein (GCKR) with serum triglycerides. The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases.
Publisher
American Association for the Advancement of Science (AAAS)
Subject
Multidisciplinary
Cited by
2442 articles.
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