1. Department of Bioinformatics, Centro de Investigación Príncipe Felipe (CIPF), Valencia, Spain, 2 European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany, 3 Functional Genomics Node (INB) at CIPF, Valencia and 4 CIBER de Enfermedades Raras (CIBERER), Valencia, Spain