Systems Biology: A Brief Overview-Reference-Cited by-同舟云学术

Systems Biology: A Brief Overview

Published:2002-03 Issue:5560 Volume:295 Page:1662-1664
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Kitano Hiroaki¹

Affiliation:

1. Sony Computer Science Laboratories, Inc., 3-14-13 Higashi-Gotanda, Shinagawa, Tokyo 141-0022, Japan, and Kitano Symbiotic Systems Project, ERATO, JST, and the Systems Biology Institute, Suite 6A, M31, 6-31-15 Jingumae, Shibuya, Tokyo 150-0001, Japan.

Abstract

To understand biology at the system level, we must examine the structure and dynamics of cellular and organismal function, rather than the characteristics of isolated parts of a cell or organism. Properties of systems, such as robustness, emerge as central issues, and understanding these properties may have an impact on the future of medicine. However, many breakthroughs in experimental devices, advanced software, and analytical methods are required before the achievements of systems biology can live up to their much-touted potential.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference29 articles.

1. N. Weiner Cybernetics or Control and Communication in the Animal and the Machine (MIT Press Cambridge MA 1948).

2. H. Kitano Foundations of Systems Biology (MIT Press Cambridge MA 2001).

3. A Genomic Regulatory Network for Development

4. Examples of such databases are: Signal Transduction Knowledge Environment (STKE ); KEGG (); EcoCyc ().

5. Cluster analysis and display of genome-wide expression patterns

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