Focal segmental glomerulosclerosis associated with the use of the IL-23 inhibitor guselkumab-Reference-Cited by-同舟云学术

Focal segmental glomerulosclerosis associated with the use of the IL-23 inhibitor guselkumab

Published:2023-07-06 Issue:10 Volume:16 Page:1701-1702
ISSN:2048-8505
Container-title:Clinical Kidney Journal
language:en
Short-container-title:

Author:

Stryckers Marijke¹,Van Oevelen Stefaan¹,Koshy Priyanka²,Sprangers Ben³⁴^ORCID,Van Craenenbroeck Amaryllis H⁵⁶

Affiliation:

1. Department of Nephrology , H. Hart-Ziekenhuis, Lier , Belgium

2. Department of Pathology, University Hospitals Leuven , Leuven , Belgium

3. Department of Nephrology , Ziekenhuis Oost-Limburg, Genk , Belgium

4. Department of Immunology and Infection, Biomedical Research Institute of the Hasselt University , Diepenbeek , Belgium

5. Department of Microbiology and Immunology, Laboratory of Nephrology of the KU Leuven , Leuven Belgium

6. Department of Neprology, University Hospitals Leuven , Leuven , Belgium

Abstract

ABSTRACT We report a case of a 38-year-old man who developed a nephrotic syndrome shortly after the start of guselkumab for the treatment of plaque psoriasis. Renal biopsy showed focal segmental glomerulosclerosis (FSGS). The clinical course of our case is highly suspect for drug-induced FSGS since the nephrotic syndrome resolved after cessation of the drug without relapse (2 years of follow-up). To the best of our knowledge, this is the first case describing FSGS lesions associated with the use of an interleukin-23 inhibitor.

Publisher

Oxford University Press (OUP)

Subject

Transplantation,Nephrology

Link

https://academic.oup.com/ckj/advance-article-pdf/doi/10.1093/ckj/sfad161/50910430/sfad161.pdf

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4. Differentiating primary, genetic, and secondary FSGS in adults: a clinicopathologic approach;De Vriese;J Am Soc Nephrol,2018

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