Calorie Restriction as a New Treatment of Inflammatory Diseases

Author:

Kökten Tunay1,Hansmannel Franck1,Ndiaye Ndeye Coumba1,Heba Anne-Charlotte1,Quilliot Didier12,Dreumont Natacha1ORCID,Arnone Djésia1,Peyrin-Biroulet Laurent13

Affiliation:

1. Université de Lorraine, Inserm U1256 NGERE (Nutrition—Genetics and Exposure to Environmental Risks), Nancy, France

2. Université de Lorraine, Centre Hospitalier Régional Universitaire (CHRU)-Nancy, Department of Diabetology-Endocrinology-Nutrition, Nancy, France

3. Université de Lorraine, Centre Hospitalier Régional Universitaire (CHRU)-Nancy, Department of Gastroenterology, Nancy, France

Abstract

ABSTRACT Immoderate calorie intake coupled with a sedentary lifestyle are major determinants of health issues and inflammatory diseases in modern society. The balance between energy consumption and energy expenditure is critical for longevity. Excessive energy intake and adiposity cause systemic inflammation, whereas calorie restriction (CR) without malnutrition, exerts a potent anti-inflammatory effect. The objective of this review was to provide an overview of different strategies used to reduce calorie intake, discuss physiological mechanisms by which CR might lead to improved health outcomes, and summarize the present knowledge about inflammatory diseases. We discuss emerging data of observational studies and randomized clinical trials on CR that have been shown to reduce inflammation and improve human health.

Funder

Association François Aupetit

Fondation pour la Recherche Médicale

Publisher

Oxford University Press (OUP)

Subject

Nutrition and Dietetics,Medicine (miscellaneous),Food Science

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