Mediterranean Diet and Telomere Length: A Systematic Review and Meta-Analysis-Reference-Cited by-同舟云学术

Mediterranean Diet and Telomere Length: A Systematic Review and Meta-Analysis

Published:2020-07-30 Issue:6 Volume:11 Page:1544-1554
ISSN:2161-8313
Container-title:Advances in Nutrition
language:en
Short-container-title:

Author:

Canudas Silvia¹²³,Becerra-Tomás Nerea¹²³⁴,Hernández-Alonso Pablo¹²³⁵,Galié Serena²³,Leung Cindy⁶^ORCID,Crous-Bou Marta⁷⁸⁹¹⁰,De Vivo Immaculata⁹¹¹¹²^ORCID,Gao Yawen⁹,Gu Yian¹³,Meinilä Jelena¹⁴,Milte Catherine¹⁵,García-Calzón Sonia¹⁶,Marti Amelia³¹⁷^ORCID,Boccardi Virginia¹⁸,Ventura-Marra Melissa¹⁹,Salas-Salvadó Jordi¹²³^ORCID

Affiliation:

1. Departament of Biochemistry and Biotechnology, Human Nutrition Unit, Universitat Rovira i Virgili. Sant Joan de Reus University Hospital, Reus, Spain

2. Pere Virgili Institut of Health (IISPV), Reus, Spain

3. Physiopathology of Obesity and Nutrition Networking Biomedical Research Center (CIBEROBN), Carlos III Health Institute, Madrid, Spain

4. Department of Preventive Medicine and Public Health, School of Medicine, University of Valencia, Valencia, Spain

5. Virgen de la Victoria University Hospital, Institute of Biomedical Research of Malaga (IBIMA)Málaga, Spain

6. Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA

7. Barcelona Beta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain

8. IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain

9. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA

10. Frailty and Healthy Ageing Networking Biomedical Researcher Center (CIBERFES), Carlos III Health Institute, Madrid, Spain

11. Channing Division of Network Medicine, Brigham and Women's Hospital - Harvard Medical School, Boston, MA, USA

12. Radcliffe Institute for Advanced Study, Harvard University, Cambridge, MA, USA

13. The Taub Institute for Research in Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York, NY, USA

14. Public Health Research Program, Folkhälsan Research Center, Helsinki, Finland

15. Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, Australia

16. Epigenetics and Diabetes Unit, Department of Clinical Sciences CRC, Lund University Diabetes Centre, Scania University Hospital, Malmö, Sweden

17. Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain

18. Department of Internal Medicine, Surgical, Neurological Metabolic Disease and Geriatric Medicine, Second University of Naples, Naples, Italy

19. Division of Animal and Nutritional Sciences, West Virginia University, Morgantown, WV, USA

Abstract

ABSTRACT Accelerated telomere shortening has been associated with several age-related diseases and/or decreased lifespan in humans. The Mediterranean diet (MedDiet) is considered to be 1 of the most recognized diets for disease prevention and healthy aging, partially due to its demonstrated anti-inflammatory and antioxidative properties which may impact on telomere length (TL). The aim of this meta-analysis was to determine the associations between MedDiet adherence and TL maintenance. MEDLINE-PubMed and Cochrane databases were searched up to December 2018 for studies evaluating the association between MedDiet adherence and TL in blood cells. Two reviewers, working independently, screened all titles and abstracts to identify studies that met the inclusion criteria [cross-sectional, case-control, and prospective cohort studies and randomized clinical trials (RCTs) published in English and excluded nonoriginal articles]. Data were pooled by the generic inverse variance method using the random effects model and expressed as standardized mean difference (SMD). Heterogeneity was identified using the Cochran Q test and quantified by the I2 statistic. A total of 8 original cross-sectional studies were included for the quantitative meta-analysis, comprising a total of 13,733 participants from 5 countries. A positive association between adherence to the MedDiet and TL was observed in all meta-analyses, with the exception of those conducted only in men: SMD (95% CI) of 0.130 (0.029; 0.231) for all subjects, 0.078 (0.005; 0.152) for women, and 0.095 (–0.005; 0.195) for men. Only 1 prospective cohort study and 1 RCT were identified, therefore, we could not undertake a meta-analysis for these study designs. The present meta-analysis of cross-sectional studies demonstrates that higher MedDiet adherence is associated with longer TL. At the same time, larger and high-quality prospective studies and clinical trials are warranted to confirm this association.

Funder

Physiopathology of Obesity and Nutrition Networking Biomedical Research Center

CIBEROBN

Carlos III Health Institute

European Regional Development Fund

Ministry of Science and Innovation

Generalitat de Catalunya

Acción Estratégica de Salud

NIH

Spanish Ministry of Health

Ministry of Economy and Business-European Regional Development Fund

ICREA