Postbiotics as potential new therapeutic agents for sepsis

Author:

Lou Xiran1,Xue Jinfang1,Shao Ruifei1,Mo Chunyan1,Wang Fuping2,Chen Guobing2

Affiliation:

1. Medical School, Kunming University of Science and Technology , 727 Jingming South Road, Chenggong District, Kunming 650500 , China

2. Department of Emergency Medicine, The First People's Hospital of Yunnan Province , 157 Jinbi Road, Xishan District, Kunming 650034 , China

Abstract

Abstract Sepsis is the main cause of death in critically ill patients and gut microbiota dysbiosis plays a crucial role in sepsis. On the one hand, sepsis leads to the destruction of gut microbiota and induces and aggravates terminal organ dysfunction. On the other hand, the activation of pathogenic gut flora and the reduction in beneficial microbial products increase the susceptibility of the host to sepsis. Although probiotics or fecal microbiota transplantation preserve gut barrier function on multiple levels, their efficacy in sepsis with intestinal microbiota disruptions remains uncertain. Postbiotics consist of inactivated microbial cells or cell components. They possess antimicrobial, immunomodulatory, antioxidant and antiproliferative activities. Microbiota-targeted therapy strategies, such as postbiotics, may reduce the incidence of sepsis and improve the prognosis of patients with sepsis by regulating gut microbial metabolites, improving intestinal barrier integrity and changing the composition of the gut microbiota. They offer a variety of mechanisms and might even be superior to more conventional ‘biotics’ such as probiotics and prebiotics. In this review, we present an overview of the concept of postbiotics and summarize what is currently known about postbiotics and their prospective utility in sepsis therapy. Overall, postbiotics show promise as a viable adjunctive therapy option for sepsis.

Funder

National Natural Science Foundation of China

Yunnan Young and Middle-aged Academic and Technical Leaders Reserve Talent Project

Yunnan Clinical Medical Center Open Project

Yunnan Key Laboratory of Stomatology Open Project

Publisher

Oxford University Press (OUP)

Subject

Critical Care and Intensive Care Medicine,Dermatology,Biomedical Engineering,Emergency Medicine,Immunology and Allergy,Surgery

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