Extending (Q)SARs to incorporate proprietary knowledge for regulatory purposes: is aromaticN-oxide a structural alert for predicting DNA-reactive mutagenicity?*

Author:

Amberg Alexander1,Anger Lennart T1,Bercu Joel2,Bower David3,Cross Kevin P3,Custer Laura4,Harvey James S5,Hasselgren Catrin6,Honma Masamitsu7,Johnson Candice3,Jolly Robert8,Kenyon Michelle O9,Kruhlak Naomi L10,Leavitt Penny4,Quigley Donald P3,Miller Scott3,Snodin David11,Stavitskaya Lidiya10,Teasdale Andrew12,Trejo-Martin Alejandra12,White Angela T5,Wichard Joerg13,Myatt Glenn J3

Affiliation:

1. Sanofi, R&D Preclinical Safety Frankfurt, Industriepark Höchst, Frankfurt am Main, Germany

2. Gilead Sciences, Nonclinical Safety and Pathobiology, Foster City, CA, USA

3. Leadscope, Inc., Columbus, OH, USA

4. Bristol-Myers Squibb, Drug Safety Evaluation, New Brunswick, NJ, USA

5. GlaxoSmithKline Pre-Clinical Development, Ware, Hertfordshire, UK

6. Genentech, Inc., Safety Assessment, South San Francisco, CA, USA

7. National Institute of Health Sciences, Division of Genetics & Mutagenesis, Kamiyoga, Setagaya-ku, Tokyo, Japan

8. Toxicology Division, Eli Lilly and Company, Indianapolis, IN, USA

9. Pfizer Worldwide Research and Development, Drug Safety, Genetic Toxicology, Groton, CT, USA

10. U.S. Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, MD, USA

11. Xiphora Biopharma Consulting, Bristol, UK

12. AstraZeneca, Pharmaceutical Technology and Development, Macclesfield, Cheshire, UK

13. Bayer AG, Pharmaceuticals Division, Investigational Toxicology, Muellerstr, Berlin, Germany

Funder

National Institute of Environmental Health Sciences

Publisher

Oxford University Press (OUP)

Subject

Health, Toxicology and Mutagenesis,Genetics (clinical),Toxicology,Genetics

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