Current Status of Methods for Defining the Applicability Domain of (Quantitative) Structure-Activity Relationships

Author:

Netzeva Tatiana I.1,Worth Andrew P.1,Aldenberg Tom2,Benigni Romualdo3,Cronin Mark T.D.4,Gramatica Paola5,Jaworska Joanna S.6,Kahn Scott7,Klopman Gilles8,Marchant Carol A.9,Myatt Glenn10,Nikolova-Jeliazkova Nina11,Patlewicz Grace Y.12,Perkins Roger13,Roberts David W.14,Schultz Terry W.15,Stanton David T.16,van de Sandt Johannes J.M.17,Tong Weida13,Veith Gilman18,Yang Chihae10

Affiliation:

1. ECVAM, Institute for Health & Consumer Protection, European Commission Joint Research Centre, Ispra, Italy;

2. RIVM, Bilthoven, The Netherlands;

3. Experimental and Computational Carcinogenesis Unit, Environment and Health Department, Istituto Superiore di Sanità, Rome, Italy;

4. School of Pharmacy and Chemistry, John Moores University, Liverpool, UK;

5. QSAR and Environmental Chemistry Research Unit, Department of Structural and Functional Biology, University of Insubria, Varese, Italy;

6. Central Product Safety, Procter & Gamble, Strombeek–Bever, Belgium;

7. Accelrys Inc., San Diego, CA, USA;

8. MULTICASE Inc., Beachwood, OH, USA;

9. Lhasa Ltd, Department of Chemistry, University of Leeds, Leeds, UK;

10. Leadscope Inc., Columbus, OH, USA;

11. Institute of Parallel Processing, Bulgarian Academy of Sciences, Sofia, Bulgaria;

12. SEAC, Unilever, Colworth House, Sharnbrook, UK;

13. Center for Toxicoinformatics, Division of Biometry and Risk Assessment, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA;

14. Bebington, Wirral, Merseyside, UK;

15. Biological Activity Testing & Modeling Laboratory, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA;

16. Miami Valley Laboratory, Procter & Gamble, Cincinnati, OH, USA;

17. Food and Chemical Risk Analysis Department, TNO, Zeist, The Netherlands;

18. Environment, Health and Safety Division, OECD, Paris, France

Publisher

SAGE Publications

Subject

Medical Laboratory Technology,Toxicology,General Biochemistry, Genetics and Molecular Biology,General Medicine

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