Affiliation:
1. Faculdade de Medicina Universidade de Lisboa, Instituto de Medicina Molecular João Lobo Antunes, Lisbon 1649-028, Portugal
2. Faculdade de Medicina Veterinária Universidade Lusófona , Lisbon 1749-024, Portugal
Abstract
Abstract
Working memory is a fundamental cognitive ability, allowing us to keep information in memory for the time needed to perform a given task. A complex neural circuit fulfills these functions, among which is the anterior cingulate cortex (CG). Functionally and anatomically connected to the medial prefrontal, retrosplenial, midcingulate and hippocampus, as well as motor cortices, CG has been implicated in retrieving appropriate information when needed to select and control appropriate behavior. The role of cingulate cortex in working memory-guided behaviors remains unclear due to the lack of studies reversibly interfering with its activity during specific epochs of working memory. We used eNpHR3.0 to silence cingulate neurons while animals perform a standard delayed non-match to trajectory task, and found that, while not causing an absolute impairment in working memory, silencing cingulate neurons during retrieval decreases the mean performance if compared to silencing during encoding. Such retrieval-associated changes are accompanied by longer delays observed when light is delivered to control animals, when compared to eNpHR3.0+ ones, consistent with an adaptive recruitment of additional cognitive resources.
Funder
FCT–—Fundação para a Ciência e a Tecnologia
Publisher
Oxford University Press (OUP)