High-Order Epistasis in Catalytic Power of Dihydrofolate Reductase Gives Rise to a Rugged Fitness Landscape in the Presence of Trimethoprim Selection-Reference-Cited by-同舟云学术

High-Order Epistasis in Catalytic Power of Dihydrofolate Reductase Gives Rise to a Rugged Fitness Landscape in the Presence of Trimethoprim Selection

Author:

Tamer Yusuf Talha¹,Gaszek Ilona K¹,Abdizadeh Haleh²³,Batur Tugce Altinusak⁴,Reynolds Kimberly A¹⁵,Atilgan Ali Rana³,Atilgan Canan³,Toprak Erdal¹⁶

Affiliation:

1. Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, TX

2. Faculty of Science and Engineering, University of Groningen, Groningen, Netherlands

3. Faculty of Engineering and Natural Sciences, Sabanci University, Istanbul, Turkey

4. Department of Internal Medicine, Dokuz Eylul University, Izmir, Turkey

5. Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX

6. Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX

Funder

UTSW Endowed Scholars Program

National Institutes of Health

EMBO Installation

Human Frontier Science Program

Scientific and Technological Research Council of Turkey

Publisher

Oxford University Press (OUP)

Subject

Genetics,Molecular Biology,Ecology, Evolution, Behavior and Systematics

Link

Reference59 articles.

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