Integrating glycomics and genomics uncovers SLC10A7 as essential factor for bone mineralization by regulating post-Golgi protein transport and glycosylation

Author:

Ashikov Angel12,Abu Bakar Nurulamin12,Wen Xiao-Yan34,Niemeijer Marco1,Rodrigues Pinto Osorio Glentino1,Brand-Arzamendi Koroboshka34,Hasadsri Linda5,Hansikova Hana6,Raymond Kimiyo5,Vicogne Dorothée7,Ondruskova Nina6,Simon Marleen E H8,Pfundt Rolph9,Timal Sharita12,Beumers Roel2,Biot Christophe7,Smeets Roel2,Kersten Marjan2,Huijben Karin2,Linders Peter T A10,van den Bogaart Geert10,van Hijum Sacha A F T1112,Rodenburg Richard13,van den Heuvel Lambertus P14,van Spronsen Francjan15,Honzik Tomas6,Foulquier Francois7,van Scherpenzeel Monique2,Lefeber Dirk J12,Mirjam Wamelink16,Han Brunner9,Helen Mundy17,Helen Michelakakis18,Peter van Hasselt19,Jiddeke van de Kamp20,Diego Martinelli21,Lars Morkrid22,Katja Brocke Holmefjord23,Jozef Hertecant24,Majid Alfadhel25,Kevin Carpenter26,Johann te Water Naude27, ,

Affiliation:

1. Department of Neurology, Donders Institute for Brain, Cognition and Behavior, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands

2. Translational Metabolic Laboratory, Department Laboratory Medicine, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands

3. Zebrafish Centre for Advanced Drug Discovery & Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael’s Hospital, Toronto, ON, Canada

4. Department of Medicine, Physiology & Institute of Medical Science, Faculty of Medicine, University of Toronto, ON, Canada

5. Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA

6. Department of Pediatrics and Adolescent Medicine, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic

7. CNRS-UMR 8576, Structural and Functional Glycobiology Unit, FRABIO, University of Lille, 59655 Villeneuve d’Ascq, France

8. Department of Genetics, University Medical Center Utrecht, Utrecht, The Netherlands

9. Department of Human Genetics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands

10. Department of Tumor Immunology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands

11. Center for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands

12. NIZO, 6710 BA Ede, The Netherlands

13. Radboud Center for Mitochondrial Disorders, Translational Metabolic Laboratory, Department of Pediatrics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands

14. Department of Pediatrics, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands

15. Division of Metabolic Diseases, Beatrix Children’s Hospital, University Medical Center Groningen, PO BOX 30.001, 9700 RB Groningen, The Netherlands

16. Department of Clinical Chemistry, VU University Medical Center, Amsterdam, The Netherlands

17. Centre for Inherited Metabolic Disease, Evelina Children's Hospital, Guys and St Thomas NHS Foundation Trust, London SE1 7EH, UK

18. Department of Enzymology and Cellular Function, Institute of Child Health, Athens, Greece

19. Department of Metabolic Diseases, University Medical Center Utrecht, Utrecht, The Netherlands

20. Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands

21. Genetics and Rare Diseases Research Division, Bambino Gesù Children's Research Hospital, Rome, Italy

22. Department of Medical Biochemistry, Oslo University Hospital, and Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway

23. Department of Child Neurology, University Hospital Stavanger, Stavanger, Norway

24. Department of Paediatrics, Tawam Hospital, Al-Ain, UAE

25. King Abdullah International Medical Research Centre, King Saud bin Abdul Aziz University for Health Sciences, Division of Genetics, Department of Pediatrics, King Abdullah Specialized Children Hospital, King Abdul Aziz Medical City, Ministry of National Guard-Health Affairs (NGHA), Riyadh, Saudi Arabia

26. NSW Biochemical Genetics Service, The Children's Hospital at Westmead, Disciplines of Genetic Medicine & Child and Adolescent Health, The University of Sydney, NSW 2145, Australia

27. Department of Child Health, University Hospital of Wales, Cardiff, UK

Funder

Netherlands Organisation for Health Research and Development

Natural Sciences and Engineering Research Council of Canada

Brain Canada Foundation

Health Canada

Ministry of Health of Malaysia

European Union Framework Programme for Research and Innovation

MZ CR AZV

Publisher

Oxford University Press (OUP)

Subject

Genetics(clinical),Genetics,Molecular Biology,General Medicine

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