Successful treatment with anakinra in generalized spiculated porokeratosis and severe hidradenitis suppurativa in a patient with <i>MVK</i> and <i>MEFV</i> mutations-Reference-Cited by-同舟云学术

Successful treatment with anakinra in generalized spiculated porokeratosis and severe hidradenitis suppurativa in a patient with MVK and MEFV mutations

Published:2022-10-28 Issue:2 Volume:48 Page:161-165
ISSN:0307-6938
Container-title:Clinical and Experimental Dermatology
language:en
Short-container-title:

Author:

Oktem Ayse¹^ORCID,Rasulova Gunel²^ORCID,Cavdarli Busra³,Bostanci Seher¹,Heper Aylin⁴,Vural Secil²^ORCID

Affiliation:

1. Department of Dermatology, Faculty of Medicine, Ankara University , Ankara , Turkiye

2. Department of Dermatology, Faculty of Medicine, Koc University , İstanbul , Turkiye

3. Department of Medical Genetics, Ankara Bilkent City Hospital , Ankara , Turkiye

4. Department of Pathology, Faculty of Medicine, Ankara University , Ankara , Turkiye

Abstract

The synergistic effect of two mutations of the innate immune system may facilitate hyperactivation and dysregulation of the inflammasome in skin macrophages. This case connects two diseases, hidradenitis suppurativa and porokeratosis, by the central role of autoinflammation.

Publisher

Oxford University Press (OUP)

Subject

Dermatology

Link

https://academic.oup.com/ced/advance-article-pdf/doi/10.1093/ced/llac023/48446292/llac023.pdf

Reference17 articles.

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