Post-acute sequelae of SARS-CoV-2 infection in health care workers from South Africa

Author:

Mbotwe-Sibanda Sthembile1ORCID,Kwatra Gaurav123,Madhi Shabir A14,Nunes Marta C15

Affiliation:

1. South African Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit, Faculty of Health Sciences, University of the Witwatersrand , Johannesburg 2050, South Africa

2. Division of Infectious Diseases, Department of Pediatrics, Cincinnati Children's Hospital Medical Center and University of Cincinnati , Cincinnati, OH 45229-3026, United States

3. Department of Clinical Microbiology, Christian Medical College , Vellore 632002, India

4. Wits Infectious Diseases and Oncology Research Institute, Faculty of Health Sciences, University of the Witwatersrand , Johannesburg 2050, South Africa

5. Center of Excellence in Respiratory Pathogens (CERP), Hospices Civils de Lyon (HCL) and Centre International de Recherche en Infectiologie (CIRI), Équipe Santé Publique, Epidémiologie et Ecologie Evolutive des Maladies Infectieuses (PHE3ID), Inserm U1111, CNRS UMR5308, ENS de Lyon, Université Claude Bernard—Lyon 1 , Lyon 6900, France

Abstract

Abstract Health care workers (HCWs) are primary health providers therefore ensuring their protection and recovery from Covid-19 is of high interest. We investigated post-acute sequelae of SARS-CoV-2 infection (PASC) in HCWs who had previously been infected with SARS-CoV-2. Overall, 68 HCWs were classified as PASC according to duration of persisting symptoms. The 68 HCWs with PASC were split into two groups according to the mean duration of their symptoms, which were (8 PASC) 122 and (60 PASC) 641 days. The frequencies of common symptoms reported by HWCs with PASC were continuous headaches (45), mild cough (41), fatigue (37), myalgia (25) and shortness of breath (14). When using the Medical Research Council (MRC) dyspnoea scale to examine the degree of breathlessness in relations to activity we found that 4 reported having difficulty breathing after strenuous exercise, 19 were identified with shortness of breath when walking fast or when walking up a slight hill, 2 reported walking slower than most people on level or stopping after 15 minutes walking at own pace, 1 reported stopping to breath after walking 91 meters, or after a few minutes on level ground and 1 reported being too breathless to leave the house, or breathless when dressing/undressing. Our results highlight concern for HCWs with long-term persisting symptoms which may negatively impact their health this represents an emerging public health priority. HCWs with prolonged Covid-19 symptoms especially breathing difficulties need better diagnostic tests and treatments.

Funder

Bill and Melinda Gates Foundation

Department of Science and Technology

National Research Foundation

South African Medical Research Council

Publisher

Oxford University Press (OUP)

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