8,9-Dihydroxy-8,9-dihydrodibenzo[ a , l ]pyrene is a potent morphological cell-transforming agent in C3H10T 1 / 2 Cl8 mouse embryo fibroblasts in the absence of detectable stable covalent DNA adducts

Author:

Nesnow Stephen,Davis Christine,Padgett William T.,Adams Linda,Yacopucci Michele,King Leon C.

Publisher

Oxford University Press (OUP)

Subject

Cancer Research,General Medicine

Reference41 articles.

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3. Nesnow,S., Davis,C., Padgett,W., George,M., Lambert,G., Meyers,F., Allison,J., Adams,L. and King,L.C. ( 1998 ) Metabolic activation of racemic and enantiomeric trans-8,9-dihydroxy-8,9-dihydrodibenzo [ a , l ]pyrene (dibenzo[ def , p ]chrysene) to dibenzo[ a , l ]pyrene-bis-dihydrodiols by induced rat liver microsomes and a recombinant human P450 1A1 system: the role of the K-region-derived metabolic intermediates in the formation of dibenzo[ a , l ]pyrene-DNA adducts. Chem. Res. Toxicol. , 11 , 1596 –1607.

4. Mumford,J.L., Li,X., Hu,F., Lu,X.B. and Chuang,J.C. ( 1995 ) Human exposure and dosimetry of polycyclic aromatic hydrocarbons in urine from Xuan Wei, China with high lung cancer mortality associated with exposure to unvented coal smoke. Carcinogenesis , 16 , 3031 –3036.

5. Cavalieri,E.L., Higginbotham,S., RamaKrishna,N.V., Devanesan,P.D., Todorovic,R., Rogan,E.G. and Salmasi,S. ( 1991 ) Comparative dose–response tumorigenicity studies of dibenzo[ a , l ]pyrene versus 7,12-dimethylbenz[ a ]anthracene, benzo[ a ]pyrene and two dibenzo[ a , l ]pyrene dihydrodiols in mouse skin and rat mammary gland. Carcinogenesis , 12 , 1939 –1944.

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