Metabolic Activation of Racemic and Enantiomeric trans-8,9-Dihydroxy-8,9-dihydrodibenzo[a,l]pyrene (Dibenzo[def,p]chrysene) to Dibenzo[a,l]pyrene-bis-dihydrodiols by Induced Rat Liver Microsomes and a Recombinant Human P450 1A1 System: The Role of the K-Region-Derived Metabolic Intermediates in the Formation of Dibenzo[a,l]pyrene−DNA Adducts-Reference-Cited by-同舟云学术

Metabolic Activation of Racemic and Enantiomeric trans-8,9-Dihydroxy-8,9-dihydrodibenzo[a,l]pyrene (Dibenzo[def,p]chrysene) to Dibenzo[a,l]pyrene-bis-dihydrodiols by Induced Rat Liver Microsomes and a Recombinant Human P450 1A1 System: The Role of the K-Region-Derived Metabolic Intermediates in the Formation of Dibenzo[a,l]pyrene−DNA Adducts

Published:1998-11-20 Issue:12 Volume:11 Page:1596-1607
ISSN:0893-228X
Container-title:Chemical Research in Toxicology
language:en
Short-container-title:Chem. Res. Toxicol.

Author:

Nesnow Stephen¹,Davis Christine¹,Padgett William¹,George Michael¹,Lambert Guy¹,Meyers Fabienne¹,Allison Joycelyn¹,Adams Linda¹,King Leon C.¹

Affiliation:

1. Biochemistry and Pathobiology Branch, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, MD-68, Research Triangle Park, North Carolina 27711, and Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514

Publisher

American Chemical Society (ACS)

Subject

Toxicology,General Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/tx9801561

Reference54 articles.

1. International Agency for Research on Cancer (1983) Polynuclear aromatic compounds, Part 1, chemical, environmental and experimental data.Monographs on the evaluation of carcinogenic risk of chemicals to man, Vol. 32, p 477, International Agency for Research on Cancer, Lyon, France.

Cited by 13 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Cytochrome P450 1b1 in polycyclic aromatic hydrocarbon (PAH)-induced skin carcinogenesis: Tumorigenicity of individual PAHs and coal-tar extract, DNA adduction and expression of select genes in the Cyp1b1 knockout mouse;Toxicology and Applied Pharmacology;2015-09

2. Association between mutation spectra and stable and unstable DNA adduct profiles in Salmonella for benzo[a]pyrene and dibenzo[a,l]pyrene;Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis;2011-09

3. Synthesis and Identification of Major Metabolites of Environmental Pollutant Dibenzo[c,mno]chrysene;Chemical Research in Toxicology;2005-08-18

4. Microsomal Biotransformation of Benzo[ghi]perylene, a Mutagenic Polycyclic Aromatic Hydrocarbon without a “Classic” Bay Region;Chemical Research in Toxicology;2005-03-09

5. Role of cell signaling in B[a]P-induced apoptosis: characterization of unspecific effects of cell signaling inhibitors and apoptotic effects of B[a]P metabolites;Chemico-Biological Interactions;2005-01