miR-122 does not impact recognition of the HCV genome by innate sensors of RNA but rather protects the 5′ end from the cellular pyrophosphatases, DOM3Z and DUSP11
Author:
Affiliation:
1. Department of Microbiology & Immunology, University of Saskatchewan, Saskatoon, SK, Canada
2. Department of Microbiology & Immunology, McGill University, Montréal, QC, Canada
3. Department of Biochemistry, McGill University, Montréal, QC, Canada
Funder
Canadian Institutes of Health Research
Canadian Foundation for Innovation
Publisher
Oxford University Press (OUP)
Subject
Genetics
Link
http://academic.oup.com/nar/article-pdf/46/10/5139/24962352/gky273.pdf
Reference67 articles.
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2. Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA;Jopling;Science,2005
3. Masking the 5′ terminal nucleotides of the Hepatitis C virus genome by an unconventional microRNA-target RNA complex;Machlin;Proc. Natl. Acad. Sci. U.S.A.,2011
4. Therapeutic silencing of microRNA-122 in primates with chronic Hepatitis C virus infection;Lanford;Science,2010
5. Treatment of HCV infection by targeting microRNA;Janssen;N. Engl. J. Med.,2013
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