T cells go with the flow: aquaporin 4 is required for full T-cell activation-Reference-Cited by-同舟云学术

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T cells go with the flow: aquaporin 4 is required for full T-cell activation

Published:2023-04-12 Issue:6 Volume:113 Page:541-543
ISSN:1938-3673
Container-title:Journal of Leukocyte Biology
language:en
Short-container-title:

Author:

Morley Sharon Celeste¹^ORCID

Affiliation:

1. Department of Pediatrics, Division of Infectious Diseases and Department of Pathology and Immunology, Division of Immunobiology, Washington University in St. Louis School of Medicine , Campus Box 8208, 660 S. Euclid Ave, St. Louis, MO 63116 , United States

Abstract

Proximal T-cell receptor signaling and subsequent T-cell activation were reduced downstream of anti-CD3/CD28 ligation through small-molecule inhibition of the water channel aquaporin 4.

Publisher

Oxford University Press (OUP)

Subject

Cell Biology,Immunology,Immunology and Allergy

Link

https://academic.oup.com/jleukbio/advance-article-pdf/doi/10.1093/jleuko/qiad041/50094483/qiad041.pdf

Reference10 articles.

1. Water channel aquaporin 4 is required for T cell receptor mediated lymphocyte activation;Nicosia;J Leukoc Biol.,2023

2. Aquaporins: important but elusive drug targets;Verkman;Nat Rev Drug Discov,2014

3. Functionalized phenylbenzamides inhibit aquaporin-4 reducing cerebral edema and improving outcome in two models of CNS injury;Farr;Neuroscience,2019

4. Aquaporins in immune cells and inflammation: new targets for drug development;da Silva;Int J Mol Sci.,2021

5. Aquaporin 4 inhibition alters chemokine receptor expression and T cell trafficking;Nicosia;Sci Rep.,2019

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