Aquaporins: important but elusive drug targets
Author:
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Pharmacology,General Medicine
Link
http://www.nature.com/articles/nrd4226.pdf
Reference193 articles.
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3. Crane, J. M. & Verkman, A. S. Determinants of aquaporin-4 assembly in orthogonal arrays revealed by live-cell single-molecule fluorescence imaging. J. Cell Sci. 122, 813–821 (2009).
4. Rash, J. E., Yasumura, T., Hudson, C. S., Agre, P. & Nielsen, S. Direct immunogold labeling of aquaporin-4 in square arrays of astrocyte and ependymocyte plasma membranes in rat brain and spinal cord. Proc. Natl Acad. Sci. USA 95, 11981–11986 (1998).
5. Smith, A. J., Jin, B. J., Ratelade, J. & Verkman, A. S. Aggregation state determines the localization and function of M1– and M23–aquaporin-4 in astrocytes. J. Cell. Biol. 204, 559–573 (2014). This study shows the dual functions of AQP4 isoforms and arrays.
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