Target isoforms are an overlooked challenge and opportunity in chimeric antigen receptor cell therapy

Author:

Bogetofte Barnkob Mike1ORCID,Vitting-Seerup Kristoffer2ORCID,Rønn Olsen Lars2ORCID

Affiliation:

1. Centre for Cellular Immunotherapy of Haematological Cancer Odense (CITCO), Department of Clinical Immunology, Odense University Hospital, University of Southern Denmark , Odense , Denmark

2. Section for Bioinformatics, Department of Health Technology, Technical University of Denmark , Lyngby , Denmark

Abstract

Abstract The development of novel chimeric antigen receptor (CAR) cell therapies is rapidly growing, with 299 new agents being reported and 109 new clinical trials initiated so far this year. One critical lesson from approved CD19-specific CAR therapies is that target isoform switching has been shown to cause tumour relapse, but little is known about the isoforms of CAR targets in solid cancers. Here we assess the protein isoform landscape and identify both the challenges and opportunities protein isoform switching present as CAR therapy is applied to solid cancers.

Funder

Independent Research Fund

Publisher

Oxford University Press (OUP)

Subject

General Medicine

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