Effect of dietary advanced glycation end-products restriction on type 2 diabetes mellitus control: a systematic review

Abstract

Abstract Context Reducing dietary advanced glycation end-products (AGEs) may favor diabetes control. Objective Critically analyze studies about the effect of dietary AGEs restriction on inflammation, oxidative stress, and glycemic control in patients with type 2 diabetes mellitus (DM2). Data Source This systematic review was conducted according to PRISMA methodology. The PubMed, Web of Science, LILACS, and Cochrane Library databases were searched, using the terms “type 2 diabetes,” “advanced glycation end products” and “diet.” Data Extraction Seven original studies were included in this review. The duration of the studies ranged from 1 day to 16 weeks. All extracted data were compiled, compared, and critically analyzed. Data Analysis Glycemic variables were considered the primary outcomes. The secondary outcomes were glycation, inflammatory, and oxidative stress markers. Conclusion Although serum insulin, homeostasis model assessment of insulin resistance, and glycated hemoglobin values were lower after the consumption of AGEs restricted diets in most studies, there was a lack of unanimity regarding dietary AGEs’ positive effect on inflammation, oxidative stress, and blood glucose. Systematic Review Registration PROSPERO registration no. CRD42020152640.