Cross-Site Reliability of Human Induced Pluripotent stem cell-derived Cardiomyocyte Based Safety Assays Using Microelectrode Arrays: Results from a Blinded CiPA Pilot Study

Author:

Millard Daniel1ORCID,Dang Qianyu2,Shi Hong3,Zhang Xiaou4,Strock Chris5,Kraushaar Udo6,Zeng Haoyu7,Levesque Paul3,Lu Hua-Rong8,Guillon Jean-Michel9,Wu Joseph C10,Li Yingxin10,Luerman Greg11,Anson Blake12,Guo Liang1213,Clements Mike1,Abassi Yama A4,Ross James1,Pierson Jennifer14,Gintant Gary15

Affiliation:

1. Axion Biosystems Inc, Atlanta, Georgia 30309

2. US Food and Drug Administration, Center for Drug Evaluation and Research, Silver Spring, Maryland 20993

3. Bristol-Myers Squibb Company, Princeton, New Jersey 08543

4. Acea Biosciences, San Diego, California 92121

5. Cyprotex, Watertown, Massachusetts 01746

6. Naturwissenschaftliches und Medizinisches Institut, Reutlingen, Germany

7. Merck & Co., Inc., Safety & Exploratory Pharmacology Department, West Point, Pennsylvania

8. Janssen, Beerse, Belgium

9. Sanofi R&D Preclinical Safety, Paris, France

10. Stanford University School of Medicine, Stanford Cardiovascular Institute, Stanford, California

11. Ncardia, Leiden, The Netherlands

12. Cellular Dynamics International a FujiFilm, Company, Madison, Wisconsin 53508

13. Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc, Frederick, Maryland 21702

14. ILSI-Health and Environmental Sciences Institute, Washington, District of Columbia 20009

15. Integrative Pharmacology (Dept ZR13), Integrated Science and Technology. AbbVie, North Chicago, Illinois 60064

Funder

Division of Cancer Treatment and Diagnosis of the National Cancer Institute

National Cancer Institute

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Toxicology

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