Effect of PCB 126 on Hepatic Metabolism of Thyroxine and Perturbations in the Hypothalamic-Pituitary-Thyroid Axis in the Rat

Author:

Fisher Jeffrey W.,Campbell Jerry,Muralidhara Srinivasa,Bruckner James V.,Ferguson Duncan,Mumtaz Moiz,Harmon Barry,Hedge Joan M.,Crofton Kevin M.,Kim Hekap,Almekinder Tara L.

Publisher

Oxford University Press (OUP)

Subject

Toxicology

Reference42 articles.

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2. Angelique, P., Van Birgelen, J. M., Van Der Kolk, J., Fase, K. M., Bol, I., Poiger, H., Brouwer, A., Brower, A., and Van Den Berg, M. (1994). Toxic potency of 3,3′,4,4′,5-pentachlorobiphenyl relative to and in combination with 2,3,7,8-tetrachlorodibenzo-p-dioxin in a subchronic feeding study in the rat. Toxicol. Sci.127,209–221.

3. ATSDR (Agency for Toxic Substances and Disease Registry) (2000). Toxicological profile for polychlorinated biphenyls (PCBs). http://www.atsdr.cdc.gov/toxprofiles/tp17-p.pdf.

4. Beetstra, J. B., van Engelen, J. G., Karels, P., van der Hoek, H. J., de Jong, M., Docter, R., Krenning, E. P., Hennemann, G., Brouwer, A., and Visser, T. J. (1991). Thyroxine and 3,3′,5-triiodothyronine are glucuronidated in rat liver by different uridine diphosphate-glucuronyltransferases. Endocrinology128,741–746.

5. Bock, K. W., and Köhle, C. (2005). Coordinate regulation of drug metabolism xenobiotic nuclear receptors: UGTs acting together with CYPs and glucuronide transporters. Drug Met. Disp.36,595–615.

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