Prediction of Drug-Induced Hepatotoxicity Using Long-Term Stable Primary Hepatic 3D Spheroid Cultures in Chemically Defined Conditions
Author:
Affiliation:
1. Section of Pharmacogenetics, Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm SE-171 77, Sweden
Publisher
Oxford University Press (OUP)
Subject
Toxicology
Link
http://academic.oup.com/toxsci/article-pdf/163/2/655/25092890/kfy058.pdf
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3. Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease;Bell;Sci. Rep.,2016
4. Transcriptional, functional, and mechanistic comparisons of stem cell-derived hepatocytes, HepaRG cells, and three-dimensional human hepatocyte spheroids as predictive in vitro systems for drug-induced liver injury;Bell;Drug Metab. Dispos.,2017
5. Drug-induced autoimmune hepatitis: Clinical characteristics and prognosis;Björnsson;Hepatology,2010
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