Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study-Reference-Cited by-同舟云学术

Comparison of Hepatic 2D Sandwich Cultures and 3D Spheroids for Long-term Toxicity Applications: A Multicenter Study

Published:2018-01-10 Issue:2 Volume:162 Page:655-666
ISSN:1096-6080
Container-title:Toxicological Sciences
language:en
Short-container-title:

Author:

Bell Catherine C¹²,Dankers Anita C A³,Lauschke Volker M¹^ORCID,Sison-Young Rowena⁴,Jenkins Roz⁴,Rowe Cliff⁴,Goldring Chris E⁴,Park Kevin⁴,Regan Sophie L⁵,Walker Tracy⁶,Schofield Chris⁷,Baze Audrey⁸⁹,Foster Alison J⁵,Williams Dominic P⁵,van de Ven Amy W M³,Jacobs Frank³,Houdt Jos van³,Lähteenmäki Tuula¹⁰,Snoeys Jan³,Juhila Satu¹⁰,Richert Lysiane⁸¹¹,Ingelman-Sundberg Magnus¹

Affiliation:

1. Department of Physiology and Pharmacology, Section of Pharmacogenetics, Karolinska Institutet, Stockholm, Sweden

2. Pathology, Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden

3. Department of Pharmacokinetics, Dynamics and Metabolism, Janssen Pharmaceutical Companies of Johnson & Johnson, Beerse, Belgium

4. MRC Centre for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, UK

5. Safety and ADME Translational Science, Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, Cambridge, UK

6. Investigative Safety & Drug Metabolism, GlaxoSmithKline Research and Development, Ware, UK

7. GSK, Medicines Research Centre, Stevenage, UK

8. KaLy Cell, Plobsheim, France

9. UNISTRA, Strasbourg, France

10. In Vitro Biology, Orion Pharma, Espoo, Finland

11. PEPITE EA4267, University of Bourgogne Franche-Comté, Besançon, France

Publisher

Oxford University Press (OUP)

Subject

Toxicology

Link

http://academic.oup.com/toxsci/article-pdf/162/2/655/24474176/kfx289.pdf

Reference45 articles.

1. Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease;Bell;Scientific Reports,2016

2. Transcriptional, functional, and mechanistic comparisons of stem cell-derived hepatocytes, HepaRG cells, and three-dimensional human hepatocyte spheroids as predictive in vitro systems for drug-induced liver injury;Bell;Drug Metabolism and Disposition,2017

3. Kinetics and dynamics of cyclosporine A in three hepatic cell culture systems;Bellwon;Toxicology in Vitro,2015

4. Hepatic metabolism of diclofenac: Role of human CYP in the minor oxidative pathways;Bort;Biochemical Pharmacology,1999

5. Sensitive and specific radioimmunoassay for fialuridine: Initial assessment of pharmacokinetics after single oral doses to healthy volunteers;Bowsher;Antimicrobial Agents and Chemotherapy,1994

Cited by 216 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A Review of CYP-Mediated Drug Interactions: Mechanisms and In Vitro Drug-Drug Interaction Assessment;Biomolecules;2024-01-12

2. Organoid-guided Precision Hepatology for Metabolic Liver Disease;Journal of Hepatology;2024-01

3. A High-Throughput Microphysiological Liver Chip System to Model Direct and Idiosyncratic Drug-Induced Liver Injury Using Human Liver Organoids;2023-12-04

4. Human Liver Organoid Models for Assessment of Drug Toxicity at the Preclinical Stage;Endocrine, Metabolic & Immune Disorders - Drug Targets;2023-12

5. Developing Liver Microphysiological Systems for Biomedical Applications;Advanced Healthcare Materials;2023-11-27