2′-O-(2-Methoxyethyl) Nucleosides Are Not Phosphorylated or Incorporated Into the Genome of Human Lymphoblastoid TK6 Cells

Author:

Saleh Amer F1,Bachman Martin2,Priestley Catherine C3,Gooderham Nigel J4,Andersson Patrik5,Henry Scott P6,Edmunds Nicholas J1,Fellows Mick D1

Affiliation:

1. New Modalities, Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca, Cambridge, UK

2. Discovery Sciences, IMED Biotech Unit, AstraZeneca, Macclesfield, UK

3. IMED Operations, AstraZeneca, Cambridge, UK

4. Surgery and Cancer, Imperial College London, London, UK

5. New Modalities, Drug Safety and Metabolism, IMED, AstraZeneca, Gothenburg, Sweden

6. Nonclinical Development, Ionis Pharmaceuticals, Inc, Carlsbad, California

Publisher

Oxford University Press (OUP)

Subject

Toxicology

Reference38 articles.

1. 5-Hydroxymethylcytosine is a predominantly stable DNA modification;Bachman;Nat. Chem.,2014

2. RNA targeting therapeutics: Molecular mechanisms of antisense oligonucleotides as a therapeutic platform;Bennett;Annu. Rev. Pharmacol. Toxicol.,2010

3. OSWG recommendations for genotoxicity testing of novel oligonucleotide-based therapeutics;Berman;Nucleic Acid Ther.,2016

4. Studies on the growth inhibition and metabolism of 2′-deoxy-2′-fluorocytidine in cultured human lymphoblasts;Brox;Cancer Res.,1974

5. Clinical pharmacological properties of mipomersen (Kynamro), a second generation antisense inhibitor of apolipoprotein B;Crooke;Br. J. Clin. Pharmacol.,2013

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