Genotoxicity Assessment of Nanomaterials: Recommendations on Best Practices, Assays, and Methods

Author:

Elespuru Rosalie1,Pfuhler Stefan2,Aardema Marilyn J3,Chen Tao4,Doak Shareen H5,Doherty Ann6,Farabaugh Christopher S7,Kenny Julia8,Manjanatha Mugimane4,Mahadevan Brinda9,Moore Martha M10,Ouédraogo Gladys11,Stankowski Leon F7,Tanir Jennifer Y12

Affiliation:

1. Division of Biology, Chemistry and Materials Science, US Food and Drug Administration, CDRH/OSEL, Silver Spring, Maryland 20993

2. The Procter & Gamble Company, Mason Business Centre, Mason, Ohio 45040

3. Marilyn Aardema Consulting LLC, Fairfield, Ohio 45014

4. Division of Genetic and Molecular Toxicology, US Food and Drug Administration, NCTR, Jefferson, Arkansas 72079

5. Institute of Life Science, Swansea University Medical School, Swansea, Wales SA2 8PP, UK

6. Discovery Safety, Drug Safety and Metabolism, IMED Biotech Unit, AstraZeneca Genetic Toxicology, AstraZeneca, Cambridge CB4 0WG, UK

7. Charles River Laboratories Skokie, LLC, Skokie, Illinois 60077

8. Genetic Toxicology & Photosafety, David Jack Centre for Research & Development, GlaxoSmithKline, Ware, Hertfordshire SG12 0DP, UK

9. Global Pre-clinical Development Innovation & Development, Established Pharmaceuticals, Abbott, Mumbai 400072, India

10. Ramboll Environ, Little Rock, Arkansas 72201

11. L’Oreal, Research & Innovation, Aulnay sous Bois, France

12. ILSI Health and Environmental Sciences Institute (HESI), Washington, District of Columbia 20005

Publisher

Oxford University Press (OUP)

Subject

Toxicology

Reference227 articles.

1. International prevalidation studies of the EpiDerm 3D human reconstructed skin micronucleus (RSMN) assay: Transferability and reproducibility;Aardema;Mutat. Res,2010

2. Comparing lipid membranes in different environments;Akabori;ACS Nano,2014

3. Determination of mutagenicity and genotoxicity of indium tin oxide nanoparticles using the Ames test and micronucleus assay;Akyıl;Toxicol. Ind. Health,2016

4. Oxidative stress contributes to cobalt oxide nanoparticles-induced cytotoxicity and DNA damage in human hepatocarcinoma cells;Alarifi;Int. J. Nanomed.,2013

5. Molecular dissection of mutations at the heterozygous thymidine kinase locus in mouse lymphoma cells;Applegate;Proc. Natl. Acad. Sci. U.S.A,1990

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