PET-detectable tau pathology correlates with long-term neuropsychiatric outcomes in patients with traumatic brain injury-Reference-Cited by-同舟云学术

PET-detectable tau pathology correlates with long-term neuropsychiatric outcomes in patients with traumatic brain injury

Published:2019-09-02 Issue:10 Volume:142 Page:3265-3279
ISSN:0006-8950
Container-title:Brain
language:en
Short-container-title:

Author:

Takahata Keisuke¹²,Kimura Yasuyuki¹³^ORCID,Sahara Naruhiko¹,Koga Shunsuke⁴^ORCID,Shimada Hitoshi¹,Ichise Masanori¹,Saito Fumie²,Moriguchi Sho¹⁵^ORCID,Kitamura Soichiro¹⁶,Kubota Manabu¹,Umeda Satoshi⁷,Niwa Fumitoshi⁸,Mizushima Jin²,Morimoto Yoko²,Funayama Michitaka⁹,Tabuchi Hajime²^ORCID,Bieniek Kevin F⁴,Kawamura Kazunori⁶,Zhang Ming-Rong¹⁰,Dickson Dennis W⁴^ORCID,Mimura Masaru²,Kato Motoichiro²,Suhara Tetsuya¹,Higuchi Makoto¹

Affiliation:

1. Department of Functional Brain Imaging Research, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan

2. Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan

3. National Center for Geriatrics and Gerontology, Aichi, Japan

4. Department of Neuroscience, Mayo Clinic, Jacksonville, USA

5. Research Imaging Centre, Centre for Addiction and Mental Health, Toronto, Canada

6. Department of Psychiatry, Nara Medical University, Nara, Japan

7. Department of Psychology, Keio University, Tokyo, Japan

8. Department of Neurology, Kyoto Prefectural University of Medicine, Kyoto, Kyoto, Japan

9. Department of Psychiatry, Japanese Red Cross Ashikaga Hospital, Ashikaga, Tochigi, Japan

10. Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba, Japan

Abstract

Is tau load associated with long-term outcomes of TBI? By using PET to assess tau deposits in patients with chronic TBI, Takahata et al. reveal elevated tau load compared to age-matched controls, and show that the abundance of tau in white matter is associated with late-onset neuropsychiatric symptoms.

Funder

Grants-in-Aid for Brain Mapping by Integrated Neurotechnologies for Disease Studies

Research and Development Grants for Dementia

Japan Agency for Medical Research and Development

JSPS

KAKENHI

Publisher

Oxford University Press (OUP)

Subject

Neurology (clinical)

Link

http://academic.oup.com/brain/advance-article-pdf/doi/10.1093/brain/awz238/29315513/awz238.pdf

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