High dose vitamin D exacerbates central nervous system autoimmunity by raising T-cell excitatory calcium

Abstract

Patients with multiple sclerosis are often given vitamin D supplements. However, Häusler, Torke et al. show an unexpected exacerbation of experimental autoimmune encephalomyelitis in mice given high but not moderate doses of supplementary vitamin D. Continuous high-dose vitamin D caused secondary hypercalcaemia, which promoted pro-inflammatory T-cell responses.