What is known about the effects of vitamin D in neuropsychiatric lupus?

Author:

Karnopp Thaís EvelynORCID,da Silva Freitas Vinicius,Di Domenico Andressa Leite,Chapacais Gustavo Flores,dos Santos Natália Garcia,Freitas Eduarda Correa,Gasparin Andrese Aline,Monticielo Odirlei André

Abstract

AbstractSystemic lupus erythematosus (SLE) is an autoimmune disease that can affect several organs and systems. The central and/or peripheral nervous system can suffer from complications known as neuropsychiatric lupus (NPSLE). Studies have associated the manifestations of SLE or NPSLE with vitamin D deficiency. It has been shown that hypovitaminosis D can lead to cognition deficits and cerebral hypoperfusion in patients with NPSLE. In this review article, we will address the main features related to vitamin D supplementation or serum vitamin D levels with neuropsychiatric manifestations, either in patients or in animal models of NPSLE. Graphical abstract

Funder

Fundo de Incentivo a Pesquisa do Hospital de Clínicas de Porto Alegre

Fundação de Apoio à Pesquisa do Rio Grande do Norte

Publisher

Springer Science and Business Media LLC

Subject

Rheumatology

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