Tau PET in autosomal dominant Alzheimer’s disease: relationship with cognition, dementia and other biomarkers

Author:

Gordon Brian A1234,Blazey Tyler M1,Christensen Jon1,Dincer Aylin1,Flores Shaney1,Keefe Sarah1,Chen Charles1,Su Yi5,McDade Eric M26,Wang Guoqiao6,Li Yan6,Hassenstab Jason246,Aschenbrenner Andrew26,Hornbeck Russ1,Jack Clifford R7,Ances Beau M236,Berman Sarah B8,Brosch Jared R9,Galasko Douglas10,Gauthier Serge11,Lah James J12,Masellis Mario13,van Dyck Christopher H14,Mintun Mark A15,Klein Gregory16,Ristic Smiljana17,Cairns Nigel J236,Marcus Daniel S1,Xiong Chengjie218,Holtzman David M236,Raichle Marcus E136,Morris John C26,Bateman Randall J236,Benzinger Tammie L S12

Affiliation:

1. Mallinckrodt Institute of Radiology, Washington University in St. Louis, MO, USA

2. Knight Alzheimer’s Disease Research Center, Washington University in St. Louis MO, USA

3. The Hope Center for Neurological Disorders, St. Louis, MO, USA

4. Department of Psychological and Brain Sciences, Washington University in St. Louis MO, USA

5. Banner Health, Phoenix AZ, USA

6. Department of Neurology, Washington University in St. Louis MO, USA

7. Department of Radiology, Mayo Clinic, Rochester, MN, USA

8. Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA

9. Department of Neurology, Indiana University, Indianapolis, IN, USA

10. Department of Neurosciences, University of California, San Diego, CA, USA

11. Departments of Psychiatry, Neurology and Neurosurgery, and Medicine, McGill University, Montreal, Canada

12. Department of Neurology, Emory University, Atlanta, GA, USA

13. Division of Neurology, Sunnybrook Health Sciences Centre; Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute; Department of Medicine, University of Toronto, Toronto, ON, Canada

14. Alzheimer’s Disease Research Unit, Yale University School of Medicine, New Haven, CT, USA

15. Avid Radiopharmaceuticals (A Wholly Owned Subsidiary of Eli Lilly and Company), Philadelphia, PA, USA

16. Roche Pharma Research and Early Development, Basel, Switzerland

17. Roche/Genentech Product Development, Neuroscience, Basel, Switzerland

18. Department of Biostatistics, Washington University in St. Louis, MO, USA

Funder

National Institutes of Health

NIH

FNIH and Accelerating Medicines Partnership

German Center for Neurodegenerative Diseases

DZNE

National Institute for Health Research

NIHR

Queen Square Dementia Biomedical Research Centre

Medical Research Council Dementias Platform UK

the Alzheimer’s Association

Eli Lilly and Company

Genentech/Roche

Avid Radiopharmaceuticals

DIAN-TU Pharma Consortium

Publisher

Oxford University Press (OUP)

Subject

Clinical Neurology

Reference70 articles.

1. White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer’s disease;Araque Caballero;Brain,2018

2. Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer’s disease;Arriagada;Neurology,1992

3. Influence of tau PET, amyloid PET, and hippocampal volume on cognition in Alzheimer disease;Aschenbrenner;Neurology,2018

4. Clinical and biomarker changes in dominantly inherited Alzheimer’s disease;Bateman;N Engl J Med,2012

5. Controlling the false discovery rate: a practical and powerful approach to multiple testing;Benjamini;J R Stat Soc Ser B,1995

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