The clinical and genetic spectrum of catecholaminergic polymorphic ventricular tachycardia: findings from an international multicentre registry

Author:

Roston Thomas M1,Yuchi Zhiguang1,Kannankeril Prince J2,Hathaway Julie3,Vinocur Jeffrey M4,Etheridge Susan P5,Potts James E1,Maginot Kathleen R6,Salerno Jack C7,Cohen Mitchell I8,Hamilton Robert M9,Pflaumer Andreas10,Mohammed Saira1,Kimlicka Lynn1,Kanter Ronald J11,LaPage Martin J12,Collins Kathryn K13,Gebauer Roman A14,Temple Joel D15,Batra Anjan S16,Erickson Christopher17,Miszczak-Knecht Maria18,Kubuš Peter19,Bar-Cohen Yaniv20,Kantoch Michal21,Thomas Vincent C17,Hessling Gabriele22,Anderson Chris23,Young Ming-Lon24,Choi Sally H J1,Cabrera Ortega Michel25,Lau Yung R26,Johnsrude Christopher L27,Fournier Anne28,Van Petegem Filip1,Sanatani Shubhayan1

Affiliation:

1. Departments of Pediatrics/Medicine/Biochemistry & Molecular Biology, University of British Columbia, 4480 Oak Street, Room 1F3, Vancouver, BC, V6H 3V4, Canada

2. Department of Pediatrics and the Vanderbilt Center for Arrhythmia Research and Therapeutics (VanCART) Vanderbilt University Medical Center and the Monroe Carell Jr. Children's Hospital at Vanderbilt, 2200 Children's Way, Suite 5230, Nashville, TN 37232-9119, USA

3. BC Inherited Arrhythmia Program, 211-1033 Davie St, Vancouver, BC V6E 1M7, Canada

4. Department of Pediatrics, University of Rochester, 601 Elmwood Ave, Box 631, Rochester, NY 14642, USA

5. Department of Pediatrics, University of Utah, 81 N Mario Capecchi Drive Salt Lake City, UT 84113, USA

6. Department of Pediatrics, University of Wisconsin School of Medicine and Public Health, 1675 Highland Ave, Madison, WI 53792, USA

7. Department of Pediatrics, University of Washington, 4800 Sand Point Way NE, Seattle, WA 98105, USA

8. Division of Cardiology Phoenix Children's Hospital, 1919 E. Thomas Road, 2nd Floor, Heart Center, Phoenix, AZ 85016, USA

9. Department of Pediatrics, University of Toronto, Hospital for Sick Children, 555 University Avenue Toronto, Ontario M5G 1X8, Canada

10. Royal Children's Hospital MCRI and University of Melbourne, 50 Flemington Road Parkville, Melbourne 3052, Australia

11. Nicklaus Children's Hospital, 3100 SW 62 Ave, Cardiology ACB - 2nd Floor Miami, FL 33155, USA

12. Department of Pediatrics, University of Michigan, 1500 E Medical Center Drive, #6303, Ann Arbor, MI 48109, USA

13. Department of Pediatrics, University of Colorado, 13123 East 16th Avenue, Aurora, CO 80045, USA

14. Department of Pediatric Cardiology, Heart Center, University of Leipzig, Strümpellstrasse 39, Leipzig, Germany

15. Department of Pediatrics, A. I. DuPont Hospital For Children, 1600 Rockland Rd, Wilmington, DE 19803, USA

16. Department of Pediatrics, University of California at Irvine Medical Center, 1140 W. La Veta Ave., Suite 750, Orange, CA 92868, USA

17. Division of Cardiology, UNMC/CUMC/Children's Hospital and Medical Center, 8200 Dodge Street, Omaha, NE 68114, USA

18. Department of Cardiology, Children's Memorial Health Institute, Dzieci Polskich 20, 04 -730 Warsaw, Poland

19. Children's Heart Centre, 2nd Faculty of Medicine, Charles University in Prague and Motol University Hospital, Vúvalu 84, 15006, Prague, Czech Republic

20. Department of Pediatrics, Children's Hospital Los Angeles, 4650 Sunset Blvd #34, Los Angeles, CA 90027, USA

21. Stollery Children's Hospital, University of Alberta, Clinical Sciences Building, 8440 112 St NW, Edmonton, AB T6G 2B7, Canada

22. Department of Electrophysiology, German Heart Center Munich, Technical University, Lazarettstr. 3680636 Munich, Germany

23. Providence Sacred Heart Children's Hospital, 101 W. 8th Ave. Suite 4300E, Spokane, WA 99204, USA

24. Department of Pediatrics, Joe DiMaggio Children's Hospital, 1150 North 35th Avenue Suite 575, Hollywood, FL 33021, USA

25. Department of Arrhythmia and Cardiac Pacing, Cardiocentro Pediatrico William Soler, 100 y perla, Boyeros. 10800, Havana, Cuba

26. Division of Pediatric Cardiology, University of Alabama at Birmingham, 1700 6th Ave S, Birmingham, AL 35233, USA

27. Department of Pediatrics, University of Louisville, 601 S Floyd St #602, Louisville, KY 40208, USA

28. Département de Pédiatrie, CHU Ste Justine, 3175, chemin Côte Sainte-Catherine, Montréal, QC H3T 1C5 Canada

Funder

National Institutes of Health

Publisher

Oxford University Press (OUP)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine

Reference25 articles.

1. Catecholaminergic polymorphic ventricular tachycardia in children: a 7-year follow-up of 21 patients;Leenhardt;Circulation,1995

2. Mutations in the cardiac ryanodine receptor gene (hRyR2) underlie catecholaminergic polymorphic ventricular tachycardia;Priori;Circulation,2001

3. Incidence and risk factors of arrhythmic events in catecholaminergic polymorphic ventricular tachycardia;Hayashi;Circulation,2009

4. Inherited dysfunction of sarcoplasmic reticulum Ca2+ handling and arrhythmogenesis;Priori;Circ Res,2011

5. A missense mutation in a highly conserved region of CASQ2 is associated with autosomal recessive catecholamine-induced polymorphic ventricular tachycardia in Bedouin families from Israel;Lahat;Am J Hum Genet,2001

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